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Open Access Green as soon as Postprint is submitted to ZB.
Compromised immune response in infants at risk for type 1 diabetes born by Caesarean Section.
Clin. Immunol. 160, 282–285 (2015)
Children born by Caesarean Section have a higher risk for type 1 diabetes. We aimed to investigate whether Caesarean Section leads to alterations of the immune response in children with familial risk for type 1 diabetes. We examined measures of innate and adaptive immune responses in 94 prospectively followed children, including 40 born by Caesarean Section. Proinflammatory serum cytokine concentrations were determined at age 6 months. As a measure of vaccine response, IgG1, IgG2, and IgG4 tetanus antibody titers and CD4(+) T cell proliferation against tetanus toxoid were quantified. Compared to infants born by vaginal delivery, infants born by Caesarean Section had lower concentrations of the cytokines IFN-ɣ (p=0.014) and IL-8 (p=0.005), and weaker CD4(+) T cell responses to tetanus measured in the first (p=0.007) and second year (p=0.047) of life. Overall, our findings provide evidence that the mode of delivery influences the immune status and responsiveness during childhood.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Caesarean Section ; Type 1 Diabetes ; Cytokine ; Immune Responsiveness ; Tetanus Response
ISSN (print) / ISBN
1521-6616
e-ISSN
1521-7035
Journal
Clinical Immunology
Quellenangaben
Volume: 160,
Issue: 2,
Pages: 282–285
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes Research Type 1 (IDF)