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John-Schuster, G. ; Günter, S. ; Hager, K. ; Conlon, T.M. ; Eickelberg, O. ; Yildirim, A.Ö.

Inflammaging increases susceptibility to cigarette smoke-induced COPD.

Oncotarget 7, 30068-30083 (2016)
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Chronic obstructive pulmonary disease (COPD) is related to an abnormal chronic inflammatory response of the lung to mainly cigarette smoke (CS) and the disease risk is increased in aged individuals. The source of this chronic inflammation is due to the repeated and progressive activation of immune cells. We hypothesize that in a chronic CS-induced mouse model, the predisposition to COPD pathogenesis in aged mice is characterized by an elevated immune response compared to young animals. We measured several characteristics of COPD in young and old mice (2 and 12 months of age) exposed to CS for 3 months. CS-exposed aged mice exhibited increased lung compliance (0.061 ± 0.008 vs. 0.055 ± 0.006 ml/cm H2O, p < 0.01), emphysema development (35.36 ± 0.71 vs. 25.31 ± 0.005 μm; p < 0.01) and airway remodeling (2.15 ± 0.37 vs. 1.09 ± 0.64 μm3/μm2; p < 0.01) compared to control animals, which was not seen in CS-exposed young mice. Quantification of lung tissue inflammation revealed a significantly greater volume of inducible bronchus-associated lymphoid tissue structures in aged mice after CS exposure (5.94 ± 2.89 vs. 2.37 ± 1.69 μm3/μm2; p < 0.01). Our results indicate that age-induced lung inflammation is further elevated after CS exposure in old mice, potentially via an age-induced change in immune cell susceptibility to CS thereby accelerating the pathophysiological hallmarks of COPD.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords B Cells ; Copd ; Aging ; Cigarette Smoke ; Ibalt; Obstructive Pulmonary-disease; Alveolar Cell Senescence; Induced Emphysema; B-cells; Lung; Mice; Association; Chemokines; Protects; Il-13
ISSN (print) / ISBN 1949-2553
e-ISSN 1949-2553
Journal OncoTarget
Quellenangaben Volume: 7, Issue: 21, Pages: 30068-30083 Article Number: , Supplement: ,
Publisher Impact Journals LLC
Publishing Place Albany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)