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Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer.
Cancer Immunol. Res. 3, 849-854 (2015)
The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers its evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Regulatory T-cells; Ifn-gamma; B7 Family; Expression; Immunotherapy; Member; Mouse
ISSN (print) / ISBN
2326-6066
e-ISSN
2326-6074
Journal
Cancer Immunology Research
Quellenangaben
Volume: 3,
Issue: 8,
Pages: 849-854
Publisher
AACR
Publishing Place
Philadelphia, Pa.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)