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Dean-Ben, X.L. ; Ford, S.J. ; Razansky, D.

High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion.

Sci. Rep. 5:10133 (2015)
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Functional imaging of mouse models of cardiac health and disease provides a major contribution to our fundamental understanding of the mammalian heart. However, imaging murine hearts presents significant challenges due to their small size and rapid heart rate. Here we demonstrate the feasibility of high-frame-rate, noninvasive optoacoustic imaging of the murine heart. The temporal resolution of 50 three-dimensional frames per second provides functional information at important phases of the cardiac cycle without the use of gating or other motion-reduction methods. Differentiation of the blood oxygenation state in the heart chambers was enabled by exploiting the wavelength dependence of optoacoustic signals. Real-time volumetric tracking of blood perfusion in the cardiac chambers was also evaluated using indocyanine green. Taken together, the newly-discovered capacities offer a unique tool set for in-vivo structural and functional imaging of the whole heart with high spatio-temporal resolution in all three dimensions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Optical Coherence Tomography; Magnetic-resonance Microscopy; In-vivo; Hypertrophic Cardiomyopathy; Echocardiography; Tracking
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 5, Issue: , Pages: , Article Number: 10133 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505590-001
PubMed ID 26130401
DOI 10.1038/srep10133
WOS ID WOS:000357163100001
Scopus ID 84934784517
Erfassungsdatum 2015-07-03
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