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Ohnmacht, C. ; Park, J.H.* ; Cording, S.* ; Wing, J.B.* ; Atarashi, K.* ; Obata, Y.* ; Gaboriau-Routhiau, V.* ; Marques, R.* ; Dulauroy, S.* ; Fedoseeva, M. ; Busslinger, M.* ; Cerf-Bensussan, N.* ; Boneca, I.G.* ; Voehringer, D.* ; Hase, K.* ; Honda, K.* ; Sakaguchi, S.* ; Eberl, G.*

The microbiota regulates type 2 immunity through RORγt+ T cells.

Science 349, 989-993 (2015)
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Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. While it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of pro-inflammatory T helper (Th) 17 cells and regulatory T cells (Tregs) in the intestine. Here, we report that microbiota-induced Tregs express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to Th17 cells. In the absence of RORγt(+) Tregs, Th2-driven defense against helminths is more efficient while Th2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of "type 3" RORγt(+) Tregs and Th17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ror-gamma-t; Innate Lymphoid-cells; Early-life; Proinflammatory Il-17(+); Commensal Bacteria; Oxazolone Colitis; Helper-cells; Differentiation; Inflammation; Susceptibility
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 349, Issue: 6251, Pages: 989-993 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-505400-001
G-505400-003
DOI 10.1126/science.aac4263
WOS ID WOS:000360646800057
PubMed ID 26160380
Erfassungsdatum 2015-07-12
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