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Barrios, C.* ; Zierer, J. ; Gudelj, I.* ; Stambuk, J.* ; Ugrina, I.* ; Rodriguez, E.* ; Soler, M.J.* ; Pavić, T.* ; Simurina, M.* ; Keser, T.* ; Pučić-Baković, M.* ; Mangino, M.* ; Pascual, J.* ; Spector, T.D.* ; Lauc, G.* ; Menni, C.*

Glycosylation profile of IgG in moderate kidney dysfunction.

J. Am. Soc. Nephrol. 27, 933-941 (2016)
Publ. Version/Full Text Supplement DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Glycans constitute the most abundant and diverse form of the post-translational modifications, and animal studies have suggested the involvement of IgG glycosylation in mechanisms of renal damage. Here, we explored the associations between IgG glycans and renal function in 3274 individuals from the TwinsUK registry. We analyzed the correlation between renal function measured as eGFR and 76 N-glycan traits using linear regressions adjusted for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. Fourteen glycan traits were associated with renal function in the discovery sample (P<6.5×10(-4)) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-acetylglucosamine of the IgG glycans. These results show the role of IgG glycosylation in kidney function and provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Clinical Nephrology ; Glycation ; Renal Function Decline; Fc-gamma-riiia; Serum Igg; Antiinflammatory Activity; Rheumatoid-arthritis; Inflammatory Diseases; Immunoglobulin-g; Galactosylation; Nephropathy; Complement; Binding
ISSN (print) / ISBN 1046-6673
e-ISSN 1533-3450
Journal Journal of the American Society of Nephrology
Quellenangaben Volume: 27, Issue: 3, Pages: 933-941 Article Number: , Supplement: ,
Publisher American Society of Nephrology
Publishing Place Washington
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)