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Open Access Green as soon as Postprint is submitted to ZB.
Opioid and dopamine antagonist drug challenges in untreated restless legs syndrome patients.
Sleep Med. 2, 57-61 (2001)
Background: The restless legs syndrome (RLS) is a common sensomotor disorder associated with severe sleep disturbances. Symptoms clearly improve following treatment with dopaminergic or opioidergic agonists.Objective: To further elucidate the involvement of opioidergic and dopaminergic mechanisms in the pathophysiology of RLS, the effects of specific antagonists on motor (periodic leg movements) and subjective (sensory) RLS-symptoms during daytime were assessed.Methods: A modified suggested immobilization test was performed in eight drug-naive RLS-patients. An infusion of either naloxone, metoclopramide or placebo was administered. In addition, the hormonal levels of adrenocorticotropic hormone, cortisol, prolactin and growth hormone were determined, to elucidate a possible involvement of the hypothalamic-pituitary-adrenocortical (HPA) system in RLS.Results: RLS sensory or motor symptoms could not be provoked. Hormonal responses showed no abnormal profiles.Conclusions: Rather than a general alteration of the opioidergic/dopaminergic tone and an involvement of the HPA system, it is more likely that specific neuronal dopaminergic or opioidergic pathways are altered in the pathophysiology of RLS.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2001
HGF-reported in Year
0
ISSN (print) / ISBN
1389-9457
e-ISSN
1878-5506
Journal
Sleep Medicine
Quellenangaben
Volume: 2,
Issue: 1,
Pages: 57-61
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500700-001
PubMed ID
11152983
Erfassungsdatum
2001-12-31