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Behr, J. ; Kreuter, M.* ; Hoeper, M.M.* ; Wirtz, H.* ; Klotsche, J.* ; Koschel, D.* ; Andreas, S.* ; Claussen, M.* ; Grohe, C.* ; Wilkens, H.* ; Randerath, W.* ; Skowasch, D.* ; Meyer, F.J.* ; Kirschner, J.* ; Glaeser, S.* ; Herth, F.J.F.* ; Welte, T.* ; Huber, R.M.* ; Neurohr, C.* ; Schwaiblmair, M.* ; Kohlhaeufl, M.* ; Hoeffken, G.* ; Held, M.* ; Koch, A.* ; Bahmer, T.* ; Pittrow, D.*

Management of patients with idiopathic pulmonary fibrosis in clinical practice: The INSIGHTS-IPF registry.

Eur. Respir. J. 46, 186-196 (2015)
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After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF) in 2011, we investigated clinical management practices for patients with IPF according to physicians' diagnoses. A prospective, multicenter, noninterventional study with comprehensive quality measures including on-site source data verification was performed in Germany. 502 consecutive patients (171 newly diagnosed, 331 prevalent; mean+-/SD age 68.7+-/9.4 years, 77.9% males) with a mean disease duration of 2.3+-/3.5 years were enrolled. IPF diagnosis was based on clinical assessments and high-resolution computed tomography (HRCT) in 90.2%, and on surgical lung biopsy combined with histology in 34.1% (lavage in 61.8%). The median 6-min walk distance was 320 m (mean 268+-/200 m). The mean forced vital capacity was 72+-/20% pred and diffusing capacity of the lung for carbon monoxide was 35+-/15% pred. No drugs were administered in 17.9%, oral steroids in 23.7%, N-acetylcysteine in 33.7%, pirfenidone in 44.2% and other drugs in 4.6% of patients. Only 2.8% of the cohort was listed for lung transplantation. IPF patients were diagnosed in line with the new guidelines. They had more severe disease than those enrolled in recent randomised controlled trials. In addition to HRCT, the frequency of lung biopsies was surprisingly high. Treatment patterns varied substantially.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Lung-function Tests; Respiratory Society; Diagnosis; Statement; Alveolitis; Guidelines; Equations; Therapy; Values; Trial
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 46, Issue: 1, Pages: 186-196 Article Number: , Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-501600-002
DOI 10.1183/09031936.00217614
WOS ID WOS:000357137300023
Erfassungsdatum 2015-02-20
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