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Doxycycline inducible melanogenic vaccinia virus as theranostic anti-cancer agent.
Theranostics 5, 1045-1057 (2015)
We reported earlier the diagnostic potential of a melanogenic vaccinia virus based system in magnetic resonance (MRI) and optoacoustic deep tissue imaging (MSOT). Since melanin overproduction lead to attenuated virus replication, we constructed a novel recombinant vaccinia virus strain (rVACV), GLV-1h462, which expressed the key enzyme of melanogenesis (tyrosinase) under the control of an inducible promoter-system. In this study melanin production was detected after exogenous addition of doxycycline in two different tumor xenograft mouse models. Furthermore, it was confirmed that this novel vaccinia virus strain still facilitated signal enhancement as detected by MRI and optoacoustic tomography. At the same time we demonstrated an enhanced oncolytic potential compared to the constitutively melanin synthesizing rVACV system.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Molecular Imaging ; Oncolysis ; Reporter Gene ; Virotherapy
e-ISSN
1838-7640
Journal
Theranostics
Quellenangaben
Volume: 5,
Issue: 10,
Pages: 1045-1057
Publisher
Ivyspring
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)