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Pinto-Teixeira, F.* ; Viader Llargues, O.* ; Torres-Mejia, E.* ; Turan, M.* ; Gonzalez-Gualda, E.* ; Pola-Morell, L.* ; López-Schier, H.

Inexhaustible hair-cell regeneration in young and aged zebrafish.

Biol. Open 4, 903-909 (2015)
Publ. Version/Full Text Supplement DOI
Open Access Gold
Creative Commons Lizenzvertrag
Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities. However, protection is not optimal for sensory systems because their external components need to be exposed to the environment to fulfill their receptive function. Thus, a common strategy to maintain sensory abilities against persistent environmental insult involves repair and regeneration. However, whether age or frequent injuries affect the regenerative capacity of sensory organs remains unknown. We have found that neuromasts of the zebrafish lateral line regenerate mechanosensory hair cells after recurrent severe injuries and in adulthood. Moreover, neuromasts can reverse transient imbalances of Notch signaling that result in defective organ proportions during repair. Our results reveal inextinguishable hair-cell regeneration in the lateral line, and suggest that the neuromast epithelium is formed by plastic territories that are maintained by continuous intercellular communication.
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Adult ; Hair Cells ; Lateral Line ; Notch ; Regeneration ; Self Organization; Lateral-line; Gene-expression; Enhancer Trap; Sensory Organ; Stem-cells; Notch; Sox2; Neuromasts
e-ISSN 2046-6390
Journal Biology Open
Quellenangaben Volume: 4, Issue: 7, Pages: 903-909 Article Number: , Supplement: ,
Publisher Company of Biologists
Publishing Place Cambridge
Non-patent literature Publications
Reviewing status Peer reviewed