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Inexhaustible hair-cell regeneration in young and aged zebrafish.
Biol. Open 4, 903-909 (2015)
Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities. However, protection is not optimal for sensory systems because their external components need to be exposed to the environment to fulfill their receptive function. Thus, a common strategy to maintain sensory abilities against persistent environmental insult involves repair and regeneration. However, whether age or frequent injuries affect the regenerative capacity of sensory organs remains unknown. We have found that neuromasts of the zebrafish lateral line regenerate mechanosensory hair cells after recurrent severe injuries and in adulthood. Moreover, neuromasts can reverse transient imbalances of Notch signaling that result in defective organ proportions during repair. Our results reveal inextinguishable hair-cell regeneration in the lateral line, and suggest that the neuromast epithelium is formed by plastic territories that are maintained by continuous intercellular communication.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adult ; Hair Cells ; Lateral Line ; Notch ; Regeneration ; Self Organization; Lateral-line; Gene-expression; Enhancer Trap; Sensory Organ; Stem-cells; Notch; Sox2; Neuromasts
e-ISSN
2046-6390
Journal
Biology Open
Quellenangaben
Volume: 4,
Issue: 7,
Pages: 903-909
Publisher
Company of Biologists
Publishing Place
Cambridge
Non-patent literature
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Reviewing status
Peer reviewed