Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Metabolic profiles during an oral glucose tolerance test in pregnant women with and without gestational diabetes.
Exp. Clin. Endocrinol. Diabet. 123, 433-438 (2015)
Background/Aim: Gestational diabetes (GDM) is a complex metabolic condition associated with hyperpglycemia that is diagnosed in an oral glucose tolerance test (OGTT) during pregnancy. For a deeper understanding of the pathology of the disease, further investigations during pregnancy are required, ideally under metabolic challenging conditions. Methods: We performed targeted metabolomics in a group of 24 well-matched women during an oral glucose tolerance test (OGTT). 231 plasma metabolites were profiled and compared to conventional clinical diagnostics. Results: A pattern of 8 metabolites differed between GDM and healthy controls as early as 30min in an OGTT (AUC 0.9770.008), and an increase in acylcarnitine C18:0, decreased concentrations of diacyl phosphatidylcholines (PC aa) C34:4, PC aa C36:4, PC aa C38:5, Lyso PC C20:4 and arachidonic acid were associated with insulin resistance. Conclusion: Our data suggest an additional value of metabolite pattern in the diagnosis of GDM and describe altered pathways that might be subjected to a more precise diagnosis and individualized therapy.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Gdm ; Glucose Tolerance Test ; Pregnancy ; Targeted Metabolomics ; Metabolites ; Insulin Resistance; Trimester Amniotic-fluid; Insulin-resistance; Prenatal Disorders; Maternal Urine; Mellitus; Biomarkers; Diagnosis; Expression; Secretion; Package
ISSN (print) / ISBN
0947-7349
e-ISSN
1439-3646
Quellenangaben
Volume: 123,
Issue: 7,
Pages: 433-438
Publisher
Thieme
Publishing Place
Stuttgart
Non-patent literature
Publications
Reviewing status
Peer reviewed