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Diaz-Lacava, A.N.* ; Walier, M.* ; Holler, D.* ; Steffens, M.* ; Gieger, C. ; Furlanello, C.* ; Lamina, C.* ; Wichmann, H.-E. ; Becker, T.*

Genetic geostatistical framework for spatial analysis of fine-scale genetic heterogeneity in modern populations: Results from the KORA study.

Int. J. Genomics 2015:693193 (2015)
Publ. Version/Full Text Supplement DOI PMC
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Aiming to investigate fine-scale patterns of genetic heterogeneity in modern humans from a geographic perspective, a genetic geostatistical approach framed within a geographic information system is presented. A sample collected for prospective studies in a small area of southern Germany was analyzed. None indication of genetic heterogeneity was detected in previous analysis. Socio-demographic and genotypic data of German citizens were analyzed (212 SNPs; n = 728). Genetic heterogeneity was evaluated with observed heterozygosity (H O). Best-fitting spatial autoregressive models were identified, using socio-demographic variables as covariates. Spatial analysis included surface interpolation and geostatistics of observed and predicted patterns. Prediction accuracy was quantified. Spatial autocorrelation was detected for both socio-demographic and genetic variables. Augsburg City and eastern suburban areas showed higher H O values. The selected model gave best predictions in suburban areas. Fine-scale patterns of genetic heterogeneity were observed. In accordance to literature, more urbanized areas showed higher levels of admixture. This approach showed efficacy for detecting and analyzing subtle patterns of genetic heterogeneity within small areas. It is scalable in number of loci, even up to whole-genome analysis. It may be suggested that this approach may be applicable to investigate the underlying genetic history that is, at least partially, embedded in geographic data.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Association; Stratification; Inference; Diversity; Distance; Impact
ISSN (print) / ISBN 2314-436X
e-ISSN 2314-4378
Quellenangaben Volume: 2015, Issue: , Pages: , Article Number: 693193 Supplement: ,
Publisher Hindawi
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed