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Mechanisms of beta cell dysfunction associated with viral infection.
Curr. Diab. Rep. 15:654 (2015)
Type 1 diabetes (T1D) results from genetic predisposition and environmental factors leading to the autoimmune destruction of pancreatic beta cells. Recently, a rapid increase in the incidence of childhood T1D has been observed worldwide; this is too fast to be explained by genetic factors alone, pointing to the spreading of environmental factors linked to the disease. Enteroviruses (EVs) are perhaps the most investigated environmental agents in relationship to the pathogenesis of T1D. While several studies point to the likelihood of such correlation, epidemiological evidence in its support is inconclusive or in some instances even against it. Hence, it is still unknown if and how EVs are involved in the development of T1D. Here we review recent findings concerning the biology of EV in beta cells and the potential implications of this knowledge for the understanding of beta cell dysfunction and autoimmune destruction in T1D.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Type 1 Diabetes ; Beta Cell ; Enterovirus ; Coxsackievirus
ISSN (print) / ISBN
1534-4827
e-ISSN
1539-0829
Journal
Current Diabetes Reports
Quellenangaben
Volume: 15,
Issue: 10,
Article Number: 654
Publisher
Springer
Publishing Place
Heidelberg [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)