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Ussar, S. ; Griffin, N.W.* ; Bezy, O.* ; Fujisaka, S.* ; Vienberg, S.* ; Softic, S.* ; Deng, L.* ; Bry, L.* ; Gordon, J.I.* ; Kahn, C.R.*

Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome.

Cell Metab. 22, 516-530 (2015)

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Open Access Green as soon as Postprint is submitted to ZB.

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Obesity, diabetes, and metabolic syndrome result from complex interactions between genetic and environmental factors, including the gut microbiota. To dissect these interactions, we utilized three commonly used inbred strains of mice-obesity/diabetes-prone C57Bl/6J mice, obesity/diabetes-resistant 129S1/SvImJ from Jackson Laboratory, and obesity-prone but diabetes-resistant 129S6/SvEvTac from Taconic-plus three derivative lines generated by breeding these strains in a new, common environment. Analysis of metabolic parameters and gut microbiota in all strains and their environmentally normalized derivatives revealed strong interactions between microbiota, diet, breeding site, and metabolic phenotype. Strain-dependent and strain-independent correlations were found between specific microbiota and phenotypes, some of which could be transferred to germ-free recipient animals by fecal transplantation. Environmental reprogramming of microbiota resulted in 129S6/SvEvTac becoming obesity resistant. Thus, development of obesity/metabolic syndrome is the result of interactions between gut microbiota, host genetics, and diet. In permissive genetic backgrounds, environmental reprograming of microbiota can ameliorate development of metabolic syndrome.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Intestinal Microbiota; Insulin Sensitivity; Wide Association; Systems Biology; Mice; Disease; Individuals; Homeostasis; Metagenome; Resistance

ISSN (print) / ISBN 1550-4131

e-ISSN 1932-7420

Journal Cell Metabolism

Quellenangaben Volume: 22, Issue: 3, Pages: 516-530

Publisher Elsevier

Publishing Place Cambridge

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Obesity (IDO)