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di Giuseppe, R.* ; Kuehn, T.* ; Hirche, F.* ; Buijsse, B.* ; Dierkes, J.* ; Fritsche, A. ; Kaaks, R.* ; Boeing, H.* ; Stangl, G.I.* ; Weikert, C.*

Potential predictors of plasma fibroblast growth factor 23 concentrations: Cross-sectional analysis in the EPIC-Germany study.

PLoS ONE 10:e0133580 (2015)
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Background Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population. However, what determines higher FGF23 levels is still unclear. Also, little is known about the influence of diet on FGF23. The aim of this study was therefore to identify demographic, clinical and dietary correlates of high FGF23 concentrations in the general population. Methods We performed a cross-sectional analysis within a randomly selected subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany comprising 2134 middle-aged men and women. The Human FGF23 (C-Terminal) ELISA kit was used to measure FGF23 in citrate plasma. Dietary data were obtained at baseline via validated food frequency questionnaires including up to 148 food items. Results Multivariable adjusted logistic regression showed that men had a 66% lower and smokers a 64% higher probability of having higher FGF23 (>= 90 RU/mL) levels compared, respectively, with women and nonsmokers. Each doubling in parathyroid hormone, creatinine, and C-reactive protein was related to higher FGF23. Among the dietary factors, each doubling in calcium and total energy intake was related, respectively, to a 1.75 and to a 4.41 fold increased probability of having higher FGF23. Finally, each doubling in the intake of iron was related to an 82% lower probability of having higher FGF23 levels. Results did not substantially change after exclusion of participants with lower kidney function. Conclusions In middle-aged men and women traditional and non-traditional CVD risk factors were related to higher FGF23 concentrations. These findings may contribute to the understanding of the potential mechanisms linking increased FGF23 to increased CVD risk.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Chronic Kidney-disease; Left-ventricular Hypertrophy; Cardiovascular-disease; Parathyroid-hormone; Dietary Phosphorus; Renal-function; Fgf23; Risk; Heart; Population
Language english
Publication Year 2015
HGF-reported in Year 0
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 10, Issue: 7, Pages: , Article Number: e0133580 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
German Center for Diabetes Reseach (DZD)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
DOI 10.1371/journal.pone.0133580
WOS ID WOS:000358546400105
Erfassungsdatum 2015-08-28
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