PuSH - Publication Server of Helmholtz Zentrum München: Acid-coated textiles (pH 5.5-6.5) - a new therapeutic strategy for atopic eczema?

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Jaeger, T. ; Rothmaier, M.* ; Zander, H.* ; Ring, J.* ; Gutermuth, J. ; Anliker, M.D.*

Acid-coated textiles (pH 5.5-6.5) - a new therapeutic strategy for atopic eczema?

Acta Derm.-Venereol. 95, 659-663 (2015)

Publ. Version/Full Text

DOI

	Open Access Gold

Abstract
Metrics
Extra information

Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The "acid mantle", which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, the effect of citric acid-coated textiles on atopic skin has not been examined to date. A textile carrier composed of cellulose fibres was coated with a citric acid surface layer by esterification, ensuring a constant pH of 5.5-6.5. Twenty patients with AE or atopic diathesis were enrolled in the study. In a double-blind, half-side experiment, patients had to wear these textiles for 12 h a day for 14 days. On day 0 (baseline), 7 and 14, tolerability (erythema, pruritus, eczema, wearing comfort) and efficacy on skin barrier were assessed by TEWL skin hydration (corneometry/ capacitance), pH and clinical scoring of eczema (SCO-RAD). Citric acid-coated textiles were well tolerated and improved eczema and objective parameters of skin physiology, including barrier function and a reduced skin surface pH, with potential lower pathogenic microbial colonisation.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Atopic Eczema ; Acid-coated Textiles ; Transepidermal Water Loss (tewl) ; Skin Capacitance; Citric-acid; Water-loss; Dermatitis; Filaggrin; Barrier; Functionality; Children; Efficacy; Safety

ISSN (print) / ISBN 0001-5555

e-ISSN 1651-2057

Journal Acta Dermato-Venereologica

Quellenangaben Volume: 95, Issue: 6, Pages: 659-663

Publisher Acta Dermato-Venereologica

Publishing Place Uppsala

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute for Allergy Research (IAF)