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High-resolution epi-illumination raster-scan optoacoustic mesoscopy for imaging of model organisms and microvessels.
Proc. SPIE 9539:95390U (2015)
Publ. Version/Full Text
DOI
We have developed an epi-illumination raster-scan optoacoustic mesoscopy system (RSOM), the new system is capable of imaging model organisms, and vasculature. The newly developed system is based on a custom designed; spherically focused detector with a Characterization of the system shows an isotropic lateral resolution of 18 μm, and an axial resolution of 4 μm. The scan times are on the order of 8 minutes for a field of view of 10×10 mm2. The achieved resolution is slightly degraded up to a depth of 5 mm. After characterizing the system we showcase it's performance on a zebrafish ex vivo, and an excised mouse ear. Additionally, to improve the visibility of small structures we have reconstructed the high frequencies, and the low frequencies separately, and at the end overplayed the two reconstructions using different colors, this way the high frequencies are not masked by the low frequencies which have a higher signal to noise ratio.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Frequency Analysis ; Mesoscopy ; Microcirculation ; Optoacoustic ; Photoacoustic ; Skin
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Opto-Acoustic Methods and Applications in Biophotonics II
Conference Date
22 - 23 June 2015
Conference Location
Munich, Germany
Journal
Proceedings of SPIE
Quellenangaben
Volume: 9539,
Article Number: 95390U
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)