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Open Access Green as soon as Postprint is submitted to ZB.
Simultaneous visualization of tumor oxygenation, neovascularization and contrast agent perfusion by real-time three-dimensional optoacoustic tomography.
Eur. Radiol. 26, 1843-1851 (2016)
OBJECTIVES: Intravital imaging within heterogenic solid tumours is important for understanding blood perfusion profiles responsible for establishment of multiple parameters within the tumour mass, such as hypoxic and nutrition gradients, cell viability, proliferation and drug response potentials. METHODS: Herein, we developed a method based on a volumetric multispectral optoacoustic tomography (vMSOT) for cancer imaging in preclinical models and explored its capacity for three-dimensional imaging of anatomic, vascular and functional tumour profiles in real time. RESULTS: In contrast to methods based on cross-sectional (2D) image acquisition as a basis for 3D rendering, vMSOT has attained concurrent observations from the entire tumour volume at 10 volumetric frames per second. This truly four dimensional imaging performance has enabled here the simultaneous assessment of blood oxygenation gradients and vascularization in solid breast tumours and revealed different types of blood perfusion profiles in-vivo. CONCLUSION: The newly introduced capacity for high-resolution three-dimensional tracking of fast tumour perfusion suggests vMSOT as a powerful method in preclinical cancer research and theranostics. As the imaging setup can be equally operated in both stationary and handheld mode, the solution is readily translatable for perfusion monitoring in a clinical setting. KEY POINTS: • vMSOT visualizes 3D anatomic, vascular and functional tumour profiles in real time. • Three types of blood perfusion profiles are revealed in breast tumour model. • The method is readily adaptable to operate in a handheld clinical mode.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
3d Optoacoustic Tomography ; Breast Cancer ; Molecular Imaging ; Nanoparticles ; Neovascularization; In-vivo; Photoacoustic Tomography; Cancer; Microenvironment; Tissues
ISSN (print) / ISBN
0938-7994
e-ISSN
1432-1084
Journal
European Radiology
Quellenangaben
Volume: 26,
Issue: 6,
Pages: 1843-1851
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)