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Open Access Green as soon as Postprint is submitted to ZB.
Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts.
Neurobiol. Aging 36, 2907.e13-2907.e17 (2015)
A recent study in autopsy-confirmed Parkinson's disease (PD) patients and controls revived the debate about the role of PARK10 in this disorder. In an attempt to replicate these results and further understand the role of this locus in the risk and age at onset of PD, we decided to explore NeuroX genotyping and whole exome sequencing data from 2 large independent cohorts of clinical patients and controls from the International Parkinson's Disease Genomic Consortium. A series of single-variant and gene-based aggregation (sequence kernel association test and combined multivariate and collapsing test) statistical tests suggested that common and rare genetic variation in this locus do not influence the risk or age at onset of clinical PD.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Neurox ; Neurogenetics ; Park10 ; Parkinson's Disease ; Whole Exome Sequencing
ISSN (print) / ISBN
0197-4580
e-ISSN
1558-1497
Journal
Neurobiology of Aging
Quellenangaben
Volume: 36,
Issue: 10,
Pages: 2907.e13-2907.e17
Publisher
Elsevier
Publishing Place
New York, NY [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed