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Rühm, W. ; Woloschak, G.E.* ; Shore, R.E.* ; Azizova, T.V.* ; Grosche, B.* ; Niwa, O.* ; Akiba, S.* ; Ono, T.* ; Suzuki, K.* ; Iwasaki, T.* ; Ban, N.* ; Kai, M.* ; Clement, C.H.* ; Bouffler, S.* ; Toma, H.* ; Hamada, N.*

Dose and dose-rate effects of ionizing radiation: A discussion in the light of radiological protection.

Radiat. Environ. Biophys. 54, 379-401 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The biological effects on humans of low-dose and low-dose-rate exposures to ionizing radiation have always been of major interest. The most recent concept as suggested by the International Commission on Radiological Protection (ICRP) is to extrapolate existing epidemiological data at high doses and dose rates down to low doses and low dose rates relevant to radiological protection, using the so-called dose and dose-rate effectiveness factor (DDREF). The present paper summarizes what was presented and discussed by experts from ICRP and Japan at a dedicated workshop on this topic held in May 2015 in Kyoto, Japan. This paper describes the historical development of the DDREF concept in light of emerging scientific evidence on dose and dose-rate effects, summarizes the conclusions recently drawn by a number of international organizations (e.g., BEIR VII, ICRP, SSK, UNSCEAR, and WHO), mentions current scientific efforts to obtain more data on low-dose and low-dose-rate effects at molecular, cellular, animal and human levels, and discusses future options that could be useful to improve and optimize the DDREF concept for the purpose of radiological protection.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ddref ; Dref ; Icrp ; Ldef ; Lnt Model ; Radiation Risk
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Journal Radiation and Environmental Biophysics
Quellenangaben Volume: 54, Issue: 4, Pages: 379-401 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Protection (ISS)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Radiation Sciences
PSP Element(s) G-501100-001
PubMed ID 26343037
DOI 10.1007/s00411-015-0613-6
WOS ID WOS:000364028400001
Scopus ID 84945440657
Scopus ID 84940886450
Erfassungsdatum 2015-09-09
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