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Morelli, G.* ; Song, Y.* ; Mazzoni, C.J.* ; Eppinger, M.* ; Roumagnac, P.* ; Wagner, D.M.* ; Feldkamp, M.* ; Kusecek, B.* ; Vogler, AJ.* ; Li, Y.* ; Cui, Y.* ; Thomson, NR.* ; Jombart, T.* ; Leblois, R.* ; Lichtner, P. ; Rahalison, L.* ; Petersen, J.M.* ; Balloux, F.* ; Keim, P.* ; Wirth, T.* ; Ravel, J.* ; Yang, R.* ; Carniel, E.* ; Achtman, M.*

Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity.

Nat. Genet. 42, 1140-1143 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y. pestis isolates for 933 SNPs using Sequenom MassArray SNP typing. We conducted phylogenetic analyses on this sequence variation dataset, assigned isolates to populations based on maximum parsimony and, from these results, made inferences regarding historical transmission routes. Our phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs. All 626 current isolates from the United States reflect one radiation, and 82 isolates from Madagascar represent a second radiation. Subsequent local microevolution of Y. pestis is marked by sequential, geographically specific SNPs.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords salmonella-typhi; plague; evolution; insights; strain; microevolution; phylogeography; adaptation; dynamics; history
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 42, Issue: 12, Pages: 1140-1143 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed