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Blood monocytes and their subsets: Established features and open questions.
Front. Immunol. 6:423 (2015)
In contrast to the past reliance on morphology, the identification and enumeration of blood monocytes are nowadays done with monoclonal antibodies and flow cytometry and this allows for subdivision into classical, intermediate, and non-classical monocytes. Using specific cell surface markers, dendritic cells in blood can be segregated from these monocytes. While in the past, changes in monocyte numbers as determined in standard hematology counters have not had any relevant clinical impact, the subset analysis now has uncovered informative changes that may be used in management of disease.
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Publication type
Article: Journal article
Document type
Review
Keywords
Classical Monocytes ; Intermediate Monocytes ; Monocyte Subsets ; Nomenclature ; Non-classical Monocytes; Human Peripheral-blood; Human Dendritic Cells; Predict Cardiovascular Events; Cd14(+) Cd16(+) Monocytes; Gene-expression Profiles; Chronic Kidney-disease; Fc-epsilon-ri; Bone-marrow; Cd16-positive Monocytes; M-dc8(+) Monocytes
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
Journal
Frontiers in Immunology
Quellenangaben
Volume: 6,
Article Number: 423
Publisher
Frontiers
Publishing Place
Lausanne
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)