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Schirawski, J.* ; Mannhaupt, G. ; Münch, K.* ; Brefort, T.* ; Schipper, K.* ; Doehlemann, G.* ; di Stasio, M.* ; Rössel, N.* ; Mendoza-Mendoza, A.* ; Pester, D.* ; Müller, O.* ; Winterberg, B.* ; Meyer, E.* ; Ghareeb, H.* ; Wollenberg, T.* ; Münsterkötter, M. ; Wong, P. ; Walter, M. ; Stukenbrock, E.* ; Güldener, U. ; Kahmann, R.*

Pathogenicity determinants in smut fungi revealed by genome comparison.

Science 330, 1546-1548 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Biotrophic pathogens, such as the related maize pathogenic fungi Ustilago maydis and Sporisorium reilianum, establish an intimate relationship with their hosts by secreting protein effectors. Because secreted effectors interacting with plant proteins should rapidly evolve, we identified variable genomic regions by sequencing the genome of S. reilianum and comparing it with the U. maydis genome. We detected 43 regions of low sequence conservation in otherwise well-conserved syntenic genomes. These regions primarily encode secreted effectors and include previously identified virulence clusters. By deletion analysis in U. maydis, we demonstrate a role in virulence for four previously unknown diversity regions. This highlights the power of comparative genomics of closely related species for identification of virulence determinants.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Ustilago-maydis; Sporisorium; Maize
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 330, Issue: 6010, Pages: 1546-1548 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)