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Schirawski, J.* ; Mannhaupt, G. ; Münch, K.* ; Brefort, T.* ; Schipper, K.* ; Doehlemann, G.* ; di Stasio, M.* ; Rössel, N.* ; Mendoza-Mendoza, A.* ; Pester, D.* ; Müller, O.* ; Winterberg, B.* ; Meyer, E.* ; Ghareeb, H.* ; Wollenberg, T.* ; Münsterkötter, M. ; Wong, P. ; Walter, M. ; Stukenbrock, E.* ; Güldener, U. ; Kahmann, R.*

Pathogenicity determinants in smut fungi revealed by genome comparison.

Science 330, 1546-1548 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Biotrophic pathogens, such as the related maize pathogenic fungi Ustilago maydis and Sporisorium reilianum, establish an intimate relationship with their hosts by secreting protein effectors. Because secreted effectors interacting with plant proteins should rapidly evolve, we identified variable genomic regions by sequencing the genome of S. reilianum and comparing it with the U. maydis genome. We detected 43 regions of low sequence conservation in otherwise well-conserved syntenic genomes. These regions primarily encode secreted effectors and include previously identified virulence clusters. By deletion analysis in U. maydis, we demonstrate a role in virulence for four previously unknown diversity regions. This highlights the power of comparative genomics of closely related species for identification of virulence determinants.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ustilago-maydis; Sporisorium; Maize
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 330, Issue: 6010, Pages: 1546-1548 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
POF-Topic(s) 30505 - New Technologies for Biomedical Discoveries
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503700-001
PubMed ID 21148393
DOI 10.1126/science.1195330
Scopus ID 78650100793
Erfassungsdatum 2010-12-31
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