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Open Access Green as soon as Postprint is submitted to ZB.
Investigating the role of shape on the biological impact of gold nanoparticles in vitro.
Nanomed. 10, 2643-2657 (2015)
AIM: To investigate the influence of gold nanoparticle geometry on the biochemical response of Calu-3 epithelial cells. MATERIALS & METHODS: Spherical, triangular and hexagonal gold nanoparticles (GNPs) were used. The GNP-cell interaction was assessed via atomic absorption spectroscopy (AAS) and transmission electron microscopy (TEM). The biochemical impact of GNPs was determined over 72 h at (0.0001-1 mg/ml). RESULTS: At 1 mg/ml, hexagonal GNPs reduced Calu-3 viability below 60%, showed increased reactive oxygen species production and higher expression of proapoptotic markers. A cell mass burden of 1:2:12 as well as number of GNPs per cell (2:1:3) was observed for spherical:triangular:hexagonal GNPs. CONCLUSION: These findings do not suggest a direct shape-toxicity effect. However, do highlight the contribution of shape towards the GNP-cell interaction which impacts upon their intracellular number, mass and volume dose. KEYWORDS: CD95 (APO-1/Fas); Cathepsin-B; biocompatibility; caspases; cell death; gold nanoparticles; lung epithelial cells; nanoparticle shape; nanotoxicology; reactive oxygen species
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Biocompatibility ; Caspases ; Cathepsin-b ; Cd95 (apo-1/fas) ; Cell Death ; Gold Nanoparticles ; Lung Epithelial Cells ; Nanoparticle Shape ; Nanotoxicology ; Reactive Oxygen Species
ISSN (print) / ISBN
1743-5889
e-ISSN
1748-6963
Journal
Nanomedicine
Quellenangaben
Volume: 10,
Issue: 17,
Pages: 2643-2657
Publisher
Future Medicine
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)