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de Miguel-Yanes, J.M.* ; Shrader, P.* ; Pencina, M.J.* ; Fox, C.S.* ; Manning, A.K.* ; Grant, R.W.* ; Dupuis, J.* ; Florez, J.C* ; D'Agostino, R.B, Sr.* ; Cupples, L.A.* ; Meigs, J.B* ; MAGIC Investigators (Grallert, H. ; Meisinger, C. ; Gieger, C. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.) ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.)

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

Diabetes Care 34, 121-125 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
To test if knowledge of type 2 diabetes genetic variants improves disease prediction. We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people.
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Publication type Article: Journal article
Document type Scientific Article
Keywords association analysis; susceptibility loci; variants; mellitus
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 34, Issue: 1, Pages: 121-125 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-002
G-504200-002
PubMed ID 20889853
DOI 10.2337/dc10-1265
Erfassungsdatum 2011-05-25
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