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de Miguel-Yanes, J.M.* ; Shrader, P.* ; Pencina, M.J.* ; Fox, C.S.* ; Manning, A.K.* ; Grant, R.W.* ; Dupuis, J.* ; Florez, J.C* ; D'Agostino, R.B, Sr.* ; Cupples, L.A.* ; Meigs, J.B* ; MAGIC Investigators (Grallert, H. ; Meisinger, C. ; Gieger, C. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.) ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.)

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

Diabetes Care 34, 121-125 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
To test if knowledge of type 2 diabetes genetic variants improves disease prediction. We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords association analysis; susceptibility loci; variants; mellitus
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 34, Issue: 1, Pages: 121-125 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Research Unit Molecular Epidemiology (AME)