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Insel, R.A.* ; Dunne, J.L.* ; Atkinson, M.A.* ; Chiang, J.L.* ; Dabelea, D.* ; Gottlieb, P.A.* ; Greenbaum, C.J.* ; Herold, K.C.* ; Krischer, J.P.* ; Lernmark, A.* ; Ratner, R.E.* ; Rewers, M.J.* ; Schatz, D.A.* ; Skyler, J.S.* ; Sosenko, J.M.* ; Ziegler, A.-G.

Staging presymptomatic type 1 diabetes: A scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.

Diabetes Care 38, 1964-1974 (2015)
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Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but predictable rates through distinct identifiable stages prior to the onset of symptoms. Stage 1 is defined as the presence of β-cell autoimmunity as evidenced by the presence of two or more islet autoantibodies with normoglycemia and is presymptomatic, stage 2 as the presence of β-cell autoimmunity with dysglycemia and is presymptomatic, and stage 3 as onset of symptomatic disease. Adoption of this staging classification provides a standardized taxonomy for type 1 diabetes and will aid the development of therapies and the design of clinical trials to prevent symptomatic disease, promote precision medicine, and provide a framework for an optimized benefit/risk ratio that will impact regulatory approval, reimbursement, and adoption of interventions in the early stages of type 1 diabetes to prevent symptomatic disease.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 38, Issue: 10, Pages: 1964-1974 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502100-001
PubMed ID 26404926
DOI 10.2337/dc15-1419
WOS ID WOS:000361840500036
Erfassungsdatum 2015-10-12
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