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Kempkes, B. ; Ling, P.D.*

EBNA2 and its coactivator EBNA-LP.

Curr. Top. Microbiol. Immunol. 391, 35-39 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
While all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent EBV infection is the expression of several distinct and well-defined viral latent transcription programs called latency I, II, and III. Growth transformation of B-cells by EBV in vitro is based on the concerted action of Epstein-Barr virus nuclear antigens (EBNAs) and latent membrane proteins(LMPs). EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B. The focus of this review will be to discuss the current understanding of how two of these proteins, EBNA2 and EBNA-LP, contribute to EBV-mediated B-cell growth transformation.
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Publication type Article: Journal article
Document type Scientific Article
Editors Münz, C.*
Corresponding Author
Keywords Epstein-barr-virus; Latent Membrane-protein; Lymphoblastoid Cell-lines; Signal-binding-protein; Antigen Leader Protein; Rbp-j-kappa; Nuclear-protein-2 Acidic Domain; Responsive Cis-element; Motor-neuron Protein; Human B-lymphocytes
ISSN (print) / ISBN 0070-217x
e-ISSN 0070-217X
Conference Title Epstein Barr Virus Volume 2
Quellenangaben Volume: 391, Issue: , Pages: 35-39 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed