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Elovainio, M.* ; Taipale, T.* ; Seppälä, I.* ; Mononen, N.* ; Raitoharju, E.* ; Jokela, M.* ; Pulkki-Råback, L.* ; Illig, T. ; Waldenberger, M. ; Hakulinen, C.* ; Hintsa, T.* ; Kivimäki, M.* ; Kähönen, M.* ; Keltikangas-Järvinen, L.* ; Raitakari, O.* ; Lehtimäki, T.*

Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study.

J. Psychiatr. Res. 71, 120-125 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We used genome wide expression (GWE) data of circulating blood cells and pathway analysis to investigate the inflammatory and other molecular pathways that may be associated with long-standing depressive symptoms. Participants were 607 women and 316 men (mean age 42 years) from the Young Finns Study who participated in three consecutive study phases in 2001, 2007 and 2012. Using Gene-set enrichment analyses (GSEA) we focused our analyses to pathways (available in MSigDB database) that are likely to affect immunological and inflammatory processes. GSEA were performed for blood cell GWE data in 2012. Depressive symptoms were assessed using a modified 21-item Beck Depression Inventory in each of the three study phases. Participants who scored in the top quartile of depressive symptoms in each of the three measurement points (n = 191) differed from other participants (n = 732) in several gene-set pathways related to inflammatory processes or immune-inflammatory signaling including interleukin (IL-1) pathway, and pathways related to various immuno-inflammatory processes, such as toll-like, the NEF protein, the nuclear factor kB, the kinase AKT and the mature B cell antigen receptor pathway (false discovery rates, FDRs<0.12). The results provide novel genome wide molecular evidence that support the association between chronic depressive symptoms and altered immune-inflammatory regulation.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gene Expression Depression ; Gene Set Pathways ; Gene-set Enrichment Analyses
ISSN (print) / ISBN 0022-3956
e-ISSN 1879-1379
Journal Journal of Psychiatric Research
Quellenangaben Volume: 71, Issue: , Pages: 120-125 Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)