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Lentiviral hepatitis B pseudotype entry requires NTCP and additional hepatocyte-specific factors.
J. Gen. Virol. 97, 121-127 (2016)
Publ. Version/Full Text
DOI
PMC
Hepatitis B virus (HBV) is one of the world's major unconquered infections, resulting in progressive liver disease and current treatments rarely cure infection. A major limitation to discovering new therapies is our limited knowledge of HBV entry and dissemination pathways that hinders the development of in vitro culture systems. To address this gap in our understanding we optimised the genesis of infectious lentiviral pseudoparticles (HBVpp). The recent discovery that the bile salt transporter NTCP acts as a receptor for HBV enabled us to assess the receptor dependency of HBVpp infection. HBVpp preferentially infect hepatoma cells expressing NTCP, whereas other non-liver cells engineered to express NTCP do not support infection, suggesting that additional hepatocyte-specific factors are required for HBVpp internalisation. These results highlight the value of the HBVpp system to dissect the pathways of HBV entry and dissemination.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Virus; Glycoproteins; Resistant; Mutants; Assay
ISSN (print) / ISBN
0022-1317
e-ISSN
1465-2099
Journal
Journal of General Virology
Quellenangaben
Volume: 97,
Pages: 121-127
Publisher
Society for General Microbiology
Publishing Place
Reading
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)