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Emmanouilidis, L. ; Gopalswamy, M. ; Passon, D.M.* ; Wilmanns, M.* ; Sattler, M.

Structural biology of the import pathways of peroxisomal matrix proteins.

Biochim. Biophys. Acta-Mol. Cell Res. 1863, 804-813 (2016)
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The peroxisomal proteins (peroxins) that mediate the import of peroxisomal matrix proteins have been identified. Recently, the purification of a functional peroxisomal translocon has been reported. However, the molecular details of the import pathways and the mechanisms by which the cargo is translocated into the lumen of the organelle are still poorly understood. Structural studies have begun to provide insight into molecular mechanisms of peroxisomal import pathways for cargo proteins that harbor peroxisomal targeting signals, PTS1 and PTS2, at their C- and N-termini, respectively. So far structures have been reported for binary or tertiary protein-protein interfaces, and highlight the role of intrinsically disordered regions for these interactions. Here, we provide an overview of the currently available structural biology of peroxisomal import pathways. Current challenges and future perspectives of the structural biology of peroxisomal protein translocation are discussed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Peroxisomal Matrix Proteins ; Peroxisomal Translocon ; Peroxisome Biogenesis ; Pex13 ; Pex14 ; Pex5 ; Pex7 ; Pts1 ; Pts2 ; Structural Biology; Targeting Signal Receptor; N-terminal Domain; Cerebrohepatorenal Zellweger Syndrome; Complete Dna-sequence; Ovary Cell Mutant; Acyl-coa Oxidase; Saccharomyces-cerevisiae; Pts1 Receptor; Membrane-protein; Crystal-structure
Language english
Publication Year 2016
Prepublished in Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 0167-4889
e-ISSN 1879-2596
Journal Biochimica et Biophysica Acta - Molecular Cell Research
Quellenangaben Volume: 1863, Issue: 5, Pages: 804-813 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institute of Structural Biology (STB)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503000-001
DOI 10.1016/j.bbamcr.2015.09.034
WOS ID WOS:000374071600003
Scopus ID 84961180169
Scopus ID 84951325688
PubMed ID 26450166
Erfassungsdatum 2015-12-09
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