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Open Access Green as soon as Postprint is submitted to ZB.
Oncogenic potential of hepatitis B virus encoded proteins.
Curr. Opin. Virol. 14, 109-115 (2015)
Due to the limited treatment options hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death, and hepatitis B virus (HBV) infection is the major risk factor for development of HCC worldwide. HCC is typically preceded by chronic inflammation, but may also develop in the absence of liver disease on the basis of HBV infection and even when virus replication is controlled by antivirals. In this situation, HBV antigen expression persists and direct oncogenic effects of HBV are integration of the viral DNA into the host genome as well as direct effects of viral proteins. These factors have to be taken into account in order to personalize HCC surveillance in CHB and unravel novel therapeutic approaches.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
1879-6257
e-ISSN
1879-6265
Journal
Current Opinion in Virology
Quellenangaben
Volume: 14,
Pages: 109-115
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)