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Ingersoll, M.A.* ; Spanbroek,R.* ; Lottaz, C.* ; Gautier, E.L.* ; Frankenberger, M. ; Hoffmann, R.* ; Lang, R.* ; Haniffa, M.* ; Collin, M.* ; Tacke, F.* ; Habenicht, A.J.R.* ; Ziegler-Heitbrock, L. ; Randolph, G.J.*

Comparison of gene expression profiles between human and mouse monocyte subsets.

Blood 115, 10-19 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Blood of both humans and mice contains 2 main monocyte subsets. Here, we investigated the extent of their similarity using a microarray approach. Approximately 270 genes in humans and 550 genes in mice were differentially expressed between subsets by 2-fold or more. More than 130 of these gene expression differences were conserved between mouse and human monocyte subsets. We confirmed numerous of these differences at the cell surface protein level. Despite overall conservation, some molecules were conversely expressed between the 2 species' subsets, including CD36, CD9, and TREM-1. Other differences included a prominent peroxisome proliferator-activated receptor gamma (PPARgamma) signature in mouse monocytes, which is absent in humans, and strikingly opposed patterns of receptors involved in uptake of apoptotic cells and other phagocytic cargo between human and mouse monocyte subsets. Thus, whereas human and mouse monocyte subsets are far more broadly conserved than currently recognized, important differences between the species deserve consideration when models of human disease are studied in mice.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Journal Blood
Quellenangaben Volume: 115, Issue: 3, Pages: 10-19 Article Number: , Supplement: ,
Publisher American Society of Hematology
Publishing Place Washington
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Lung Research
PSP Element(s) G-501600-012
G-501690-001
PubMed ID 19965649
DOI 10.1182/blood-2009-07-235028
Scopus ID 77449102329
Erfassungsdatum 2010-12-31
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