PuSH - Publication Server of Helmholtz Zentrum München: AP-2 is the crucial clathrin adaptor protein for CD4 downmodulation by HIV-1 Nef in primary infected CD4+ T cells.

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Gondim, M.V. ; Wiltzer-Bach, L.* ; Maurer, B.* ; Banning, C.* ; Arganaraz, E.* ; Schindler, M.

AP-2 is the crucial clathrin adaptor protein for CD4 downmodulation by HIV-1 Nef in primary infected CD4+ T cells.

J. Virol. 89, 12518-12524 (2015)

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HIV-1 Nef-mediated CD4 downmodulation involves various host factors. We investigated the importance of AP-1, AP-2, AP-3, V1H-ATPase, β-COP and ACOT8 for CD4 downmodulation in HIV-1 infected shRNA-expressing CD4+ T cells and characterized direct interaction with Nef by FRET. Binding of lentiviral Nefs to CD4 and AP-2 was conserved and only AP-2 knockdown impaired Nef-mediated CD4 downmodulation from primary T cells. Altogether, among the factors tested, AP-2 is the most important player for Nef-mediated CD4 downmodulation.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 0022-538X

e-ISSN 1098-5514

Journal Journal of Virology

Quellenangaben Volume: 89, Issue: 24, Pages: 12518-12524

Publisher American Society for Microbiology (ASM)

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)