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Open Access Green as soon as Postprint is submitted to ZB.
Three-dimensional multispectral optoacoustic mesoscopy reveals melanin and blood oxygenation in human skin in vivo.
J. Biophotonics 9, 55-60 (2016)
Optical imaging plays a major role in disease detection in dermatology. However, current optical methods are limited by lack of three-dimensional detection of pathophysiological parameters within skin. It was recently shown that single-wavelength optoacoustic (photoacoustic) mesoscopy resolves skin morphology, i.e. melanin and blood vessels within epidermis and dermis. In this work we employed illumination at multiple wavelengths for enabling three-dimensional multispectral optoacoustic mesoscopy (MSOM) of natural chromophores in human skin in vivo operating at 15-125 MHz. We employ a per-pulse tunable laser to inherently co-register spectral datasets, and reveal previously undisclosed insights of melanin, and blood oxygenation in human skin. We further reveal broadband absorption spectra of specific skin compartments. We discuss the potential of MSOM for label-free visualization of physiological biomarkers in skin in vivo. Cross-sectional optoacoustic image of human skin in vivo. The epidermal layer is characterized by melanin absorption. A vascular network runs through the dermal layer, exhibiting blood oxygenation values of 50-90%. All scale bars: 250 µm.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dermatology ; Diagnostic Imaging ; Optoacoustic Techniques ; Photoacoustic Techniques ; Spectrum Analysis
ISSN (print) / ISBN
1864-063X
e-ISSN
1864-0648
Journal
Journal of Biophotonics
Quellenangaben
Volume: 9,
Issue: 1-2,
Pages: 55-60
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)