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Open Access Green as soon as Postprint is submitted to ZB.
Lack of association between genetic risk loci for restless legs syndrome and multimorbidity.
Sleep 39, 111–115 (2015)
OBJECTIVES: Multimorbidity is a risk factor for incident restless legs syndrome (RLS). In this relationship, the potential role of known genetic risk loci for RLS has not been studied. Our aim was to evaluate whether carriers of specific RLS risk alleles have higher comorbidity burden than noncarriers. DESIGN: Two independent, population-based cohort studies in Germany: the Dortmund Health Study (DHS) and the Study of Health in Pomerania (SHIP). SETTING AND PARTICIPANTS: Age-stratified, random samples drawn from the respective population registers. DHS included 1,312 subjects and SHIP included 4,308 subjects. MEASUREMENTS: RLS status was assessed according to the RLS standard minimal criteria. A comorbidity index was calculated by summing the scores of the following conditions: diabetes, hypertension, myocardial infarction, obesity, stroke, cancer, renal disease, anemia, depression, thyroid disease, and migraine. Thirteen single nucleotide polymorphisms (SNP) previously associated with elevated risk of RLS were genotyped. Analyses were carried out on the pooled sample of the two studies. RESULTS: The mean age was 50.4+/-15.9 y, and the proportion of women was 51.4%. The mean number of comorbid conditions was 1.5+/-1.3. In multivariable regression, the mean number of comorbidities was not significantly different between carriers of any of the RLS risk alleles and noncarriers either in the total pooled sample or in those having RLS symptoms. CONCLUSIONS: Based on these results it is unlikely that known genetic risk factors for RLS would lead to increased multimorbidity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Multimorbidity ; Restless Legs Syndrome ; Risk Alleles
ISSN (print) / ISBN
0161-8105
e-ISSN
1550-9109
Journal
Sleep
Quellenangaben
Volume: 39,
Issue: 1,
Pages: 111–115
Publisher
American Academy of Sleep Medicine and the Sleep Research Society
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Neurogenomics (ING)