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Fisher, E.* ; Nitz, I.* ; Gieger, C. ; Grallert, H. ; Gohlke, H. ; Lindner, I.* ; Dahm, S.* ; Boeing, H.* ; Burwinkel, B.* ; Rathmann, W.* ; Wichmann, H.-E. ; Schrezenmeir, J.* ; Illig, T. ; Döring, F.*

Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations.

Mol. Nutr. Food Res. 51, 178-184 (2007)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The human acyl-CoA-binding protein (ACBP) is a potential candidate gene of type 2 diabetes (T2D), since it plays a central role in determining the intracellular concentration of activated fatty acids which contribute to insulin resistance. The aim of our study was to evaluate whether single nucleotide polymorphisms (SNPs) of the ACBP gene are associated with risk of T2D. Genotyping of eight SNPs (rs2084202, rs3731607, rs8192501, rs8192504, rs2244135, rs2276596, rs8192506, rs2289948) was performed in 192 incident T2D subjects and 384 matched controls of the European Prospective Investigation into Cancer and Nutrition-Potsdam cohort. A putative promoter SNP (rs2084202) of splice variant ACBP 1c showed decreased risk of T2D (odds ratio (OR) 0.63, 95% CI 0.41-0.96). The haplotype, that contained the mutant base of rs2084202 showed similar evidence for the association with disease risk as single SNP rs2084202. In a second population-based study, Cooperative Health Research in the Augsburg Region of 226 individuals with T2D and 863 control subjects a borderline significant association between rs2084202 and T2D (OR 0.72, 95% CI 0.51-1.01) was observed. In summary, we obtained evidence from two Caucasian study populations that the minor allele of ACBP rs2084202 might be associated with reduced risk of T2D.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Acyl-CoA-binding protein; Association study; Haplotype; Single nucleotide polymorphism; Type 2 diabetes
ISSN (print) / ISBN 1613-4125
e-ISSN 1613-4133
Journal Molecular Nutrition and Food Research
Quellenangaben Volume: 51, Issue: 2, Pages: 178-184 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)