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Artigas, M.S.* ; Wain, L.V.* ; Miller, S.* ; Kheirallah, A.K.* ; Huffman, J.E.* ; Ntalla, I.* ; Shrine, N.* ; Obeidat, M.* ; Trochet, H.* ; McArdle, W.L.* ; Alves, A.C.* ; Hui, J.* ; Zhao, J.H.* ; Joshi, P.K.* ; Teumer, A.* ; Albrecht, E. ; Imboden, M.* ; Rawal, R. ; Lopez, L.M.* ; Marten, J.* ; Enroth, S.* ; Surakka, I.* ; Polasek, O.* ; Lyytikäinen, L.-P.* ; Granell, R.* ; Hysi, P.G.* ; Flexeder, C. ; Mahajan, A.* ; Beilby, J.* ; Bossé, Y.* ; Brandsma, C.A.* ; Campbell, H.* ; Gieger, C. ; Gläser, S.* ; Gonzalez, J.R.* ; Grallert, H. ; Hammond, C.J.* ; Harris, S.E.* ; Hartikainen, A.L.* ; Heliövaara, M.* ; Henderson, J.* ; Hocking, L.J.* ; Horikoshi, M.* ; Hutri-Kähönen, N.* ; Ingelsson, E.* ; Johansson, Å* ; Kemp, J.P.* ; Kolcic, I.* ; Kumar, A.* ; Lind, L.* ; Melén, E.* ; Musk, A.W.* ; Navarro, P.* ; Nickle, D.C.* ; Padmanabhan, S.* ; Raitakari, O.T.* ; Ried, J.S. ; Ripatti, S.* ; Schulz, H. ; Scott, R.A.* ; Sin, D.D.* ; Starr, J.M.* ; Viñuela, A.* ; Völzke, H.* ; Wild, S.H.* ; Wright, A.F.* ; Zemunik, T.* ; Jarvis, D.L.* ; Spector, T.D.* ; Evans, D.M* ; Lehtimäki, T.* ; Kähönen, M.* ; Gyllensten, U.* ; Rudan, I.* ; Deary, I.J.* ; Karrasch, S. ; Probst-Hensch, N.M.* ; Heinrich, J. ; Stubbe, B.* ; Wilson, J.F.* ; Wareham, N.J.* ; James, A.L.* ; Morris, A.P.* ; Jarvelin, M.R.* ; Hayward, C.* ; Sayers, I.* ; Hall, I.P.* ; Tobin, M.D.*

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Nat. Commun. 6:8658 (2015)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 6, Issue: , Pages: , Article Number: 8658 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-003
G-503900-001
G-504091-004
G-504091-002
G-504100-001
DOI 10.1038/ncomms9658
WOS ID WOS:000367589100001
Scopus ID 84949293492
PubMed ID 26635082
Erfassungsdatum 2015-12-09
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