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Artigas, M.S.* ; Wain, L.V.* ; Miller, S.* ; Kheirallah, A.K.* ; Huffman, J.E.* ; Ntalla, I.* ; Shrine, N.* ; Obeidat, M.* ; Trochet, H.* ; McArdle, W.L.* ; Alves, A.C.* ; Hui, J.* ; Zhao, J.H.* ; Joshi, P.K.* ; Teumer, A.* ; Albrecht, E. ; Imboden, M.* ; Rawal, R. ; Lopez, L.M.* ; Marten, J.* ; Enroth, S.* ; Surakka, I.* ; Polasek, O.* ; Lyytikäinen, L.-P.* ; Granell, R.* ; Hysi, P.G.* ; Flexeder, C. ; Mahajan, A.* ; Beilby, J.* ; Bossé, Y.* ; Brandsma, C.A.* ; Campbell, H.* ; Gieger, C. ; Gläser, S.* ; Gonzalez, J.R.* ; Grallert, H. ; Hammond, C.J.* ; Harris, S.E.* ; Hartikainen, A.L.* ; Heliövaara, M.* ; Henderson, J.* ; Hocking, L.J.* ; Horikoshi, M.* ; Hutri-Kähönen, N.* ; Ingelsson, E.* ; Johansson, Å* ; Kemp, J.P.* ; Kolcic, I.* ; Kumar, A.* ; Lind, L.* ; Melén, E.* ; Musk, A.W.* ; Navarro, P.* ; Nickle, D.C.* ; Padmanabhan, S.* ; Raitakari, O.T.* ; Ried, J.S. ; Ripatti, S.* ; Schulz, H. ; Scott, R.A.* ; Sin, D.D.* ; Starr, J.M.* ; Viñuela, A.* ; Völzke, H.* ; Wild, S.H.* ; Wright, A.F.* ; Zemunik, T.* ; Jarvis, D.L.* ; Spector, T.D.* ; Evans, D.M* ; Lehtimäki, T.* ; Kähönen, M.* ; Gyllensten, U.* ; Rudan, I.* ; Deary, I.J.* ; Karrasch, S. ; Probst-Hensch, N.M.* ; Heinrich, J. ; Stubbe, B.* ; Wilson, J.F.* ; Wareham, N.J.* ; James, A.L.* ; Morris, A.P.* ; Jarvelin, M.R.* ; Hayward, C.* ; Sayers, I.* ; Hall, I.P.* ; Tobin, M.D.*

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Nat. Commun. 6:8658 (2015)

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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.

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Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 2041-1723

e-ISSN 2041-1723

Journal Nature Communications

Quellenangaben Volume: 6, Article Number: 8658

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)
Institute of Genetic Epidemiology (IGE)