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Fechner, S.* ; Alvarez, L.* ; Bönigk, W.* ; Müller, A.* ; Berger, T.* ; Pascal, R.* ; Trötschel, C.* ; Poetsch, A.* ; Stölting, G.* ; Siegfried, K.R.* ; Kremmer, E. ; Seifert, R.* ; Kaupp, U.B.*

A K+ selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm.

eLife 4:e07624 (2015)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Calcium in the flagellum controls sperm navigation. In sperm of marine invertebrates and mammals, Ca2(+) signalling has been intensely studied, whereas for fish little is known. In sea urchin sperm, a cyclic nucleotide-gated K(+) channel (CNGK) mediates a cGMP-induced hyperpolarization that evokes Ca2(+) influx. Here, we identify in sperm of the freshwater fish Danio rerio a novel CNGK family member featuring non-canonical properties. It is located in the sperm head rather than the flagellum and is controlled by intracellular pH, but not cyclic nucleotides. Alkalization hyperpolarizes sperm and produces Ca2(+) entry. Ca2(+) induces spinning-like swimming, different from swimming of sperm from other species. The 'spinning' mode probably guides sperm into the micropyle, a narrow entrance on the surface of fish eggs. A picture is emerging of sperm channel orthologues that employ different activation mechanisms and serve different functions. The channel inventories probably reflect adaptations to species-specific challenges during fertilization.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Biophysics ; Cell Biology ; Structural Biology ; Zebrafish; Sea-urchin Sperm; Nucleotide-binding Domain; Loti K1 Channel; Human Spermatozoa; Catsper Channel; Ion Channels; Controls Chemosensation; Motility Initiation; Rod Photoreceptors; Cyclic-nucleotides
Language english
Publication Year 2015
HGF-reported in Year 2015
ISSN (print) / ISBN 2050-084X
e-ISSN 2050-084X
Journal eLife
Quellenangaben Volume: 4, Issue: , Pages: , Article Number: e07624 Supplement: ,
Publisher eLife Sciences Publications
Publishing Place Cambridge
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501793-001
PubMed ID 26650356
DOI 10.7554/eLife.07624
WOS ID WOS:000373807500001
Scopus ID 84956917327
Erfassungsdatum 2015-12-31
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