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The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
eLife 5:e09584 (2016)
The timely transition from neural progenitor to post-mitotic neuron requires down-regulation and loss of the neuronal transcriptional repressor, REST. Here, we have used mice containing a gene trap in the Rest gene, eliminating transcription from all coding exons, to remove REST prematurely from neural progenitors. We find that catastrophic DNA damage occurs during S-phase of the cell cycle, with long-term consequences including abnormal chromosome separation, apoptosis, and smaller brains. Persistent effects are evident by latent appearance of proneural glioblastoma in adult mice deleted additionally for the tumor suppressor p53 protein (p53). A previous line of mice deleted for REST in progenitors by conventional gene targeting does not exhibit these phenotypes, likely due to a remaining C-terminal peptide that still binds chromatin and recruits co-repressors. Our results suggest that REST-mediated chromatin remodeling is required in neural progenitors for proper S-phase dynamics, as part of its well-established role in repressing neuronal genes until terminal differentiation.
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8.303
1.230
36
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Rest Complex ; Developmental Biology ; Genomic Instability ; Knockout Animals ; Mouse ; Neurogenesis ; Repression ; Stem Cells ; Transcription Factors
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
2050-084X
e-ISSN
2050-084X
Journal
eLife
Quellenangaben
Volume: 5,
Article Number: e09584
Publisher
eLife Sciences Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500500-001
PubMed ID
26745185
WOS ID
WOS:000368225700001
Erfassungsdatum
2016-01-11