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Time, frequency and information domain analysis of heart period and QT variability in asymptomatic long QT syndrome type 2 patients.
In: (37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, 25-29 August 2015, Milan, Italy). Institute of Electrical and Electronics Engineers (IEEE), 2015. 294-297 (Conf. Proc. IEEE Eng. Med. Biol. Soc. ; 2015)
This study was designed to characterize in time, frequency and information domains heart period (HP) and QT interval variabilities in asymptomatic (ASYMP) long QT syndrome type 2 (LQT2) subjects. HP, approximated as the temporal distance between two consecutive R-wave peaks, and QT, approximated as the temporal distance between the R-wave peak and the T-wave offset, were automatically derived from 24h Holter recordings in 10 ASYMP LQT2 patients and 13 healthy non mutation carriers (NMC) subjects. All analyses were carried out during DAY (from 2 to 6 PM) and NIGHT (from 12 to 4 AM). Mean, variance, spectral power and complexity indices at short, medium and long time scales were assessed over HP and QT beat-to-beat series. Circadian rhythmicity was evident in both NMC and ASYMP LQT2 but ASYMP LQT2 subjects were characterized by higher HP, QT interval and HP variability during both DAY and NIGHT. In addition, multiscale complexity analysis was able to differentiate the groups by showing a higher HP complexity and a lower QT complexity at long time scales in ASYMP LQT2 during DAY. ASYMP LQT2 exhibited a different autonomic control compared to NMC and such a differentiation could be protective and assure them a lower risk profile.
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Publication type
Article: Conference contribution
Keywords
Complexity theory, Heart, Modulation, Entropy, Time-frequency analysis, Electronic mail, time-domain analysis, cardiology, circadian rhythms, diseases, frequency-domain analysis; multiscale complexity analysis, time domain analysis, frequency domain analysis, information domain analysis, heart period, QT variability, asymptomatic long QT syndrome type 2 patients, temporal distance, R-wave peaks, non mutation carriers, circadian rhythmicity
Language
english
Publication Year
2015
HGF-reported in Year
0
ISSN (print) / ISBN
1557-170X
Conference Title
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Conference Date
25-29 August 2015
Conference Location
Milan, Italy
Quellenangaben
Volume: 2015,
Pages: 294-297
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500700-001
PubMed ID
26736258
Scopus ID
84953328004
Erfassungsdatum
2016-02-10