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Saugel, B.* ; Jakobus, J.* ; Huber, W.* ; Hoffmann, D. ; Holzapfel, K.* ; Protzer, U. ; Schmid, R.M.* ; Umgelter, A.*

Herpes simplex virus in bronchoalveolar lavage fluid of medical intensive care unit patients: Association with lung injury and outcome.

J. Crit. Care 32, 138-144 (2016)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Purpose: In intensive care unit (ICU) patients in whom bronchoalveolar lavage fluid (BALF) was analyzed for suspected infectious pulmonary disease, we investigated the association of herpes simplex virus (HSV) in the BALF with lung injury and patient outcome. Materials and methods: In this retrospective cohort study, we included 201 patients treated in a medical ICU of a German university hospital in whom BALF samples were analyzed for the presence of HSV using quantitative polymerase chain reaction analysis. Results: Eighty-seven patients (43%) were HSV-negative, and 114 patients (57%) were HSV-positive. At the day of BALF sampling (day 0), there was no clinically relevant (or statistically significant) difference in the Modified Clinical Pulmonary Infection Score, Lung Injury Score, and single indicator transpulmonary thermodilution-derived extravascular lung water index and pulmonary vascular permeability index between HSV-negative patients and HSV-positive patients or HSV-positive patients with greater than 105 HSV copies/mL. The ICU and hospital length of stay was statistically significantly longer in HSV-positive patients compared with HSV-negative patients. Intensive care unit and hospital mortality was not statistically significantly different between the groups. Conclusions: We did not find a clinically relevant or statistically significant association of HSV in the BALF of medical ICU patients with lung injury or with ICU and hospital mortality.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Critical Care ; Extravascular Lung Water Index ; Pneumonia ; Pulmonary Vascular Permeability Index ; Transpulmonary Thermodilution; Respiratory-distress-syndrome; Critically-ill Patients; Vascular-permeability Index; Organ Dysfunction/failure; Mechanical Ventilation; Water; Tract; Score; Definition; Multicenter
ISSN (print) / ISBN 0883-9441
e-ISSN 1557-8615
Journal Journal of Critical Care
Quellenangaben Volume: 32, Issue: , Pages: 138-144 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)