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Open Access Green as soon as Postprint is submitted to ZB.
Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography-X-ray computed tomography.
J. Biomed. Opt. 21:15009 (2016)
Nuclear imaging plays a critical role in asthma research but is limited in its readings of biology due to the short-lived signals of radio-isotopes. We employed hybrid fluorescence molecular tomography (FMT) and x-ray computed tomography (XCT) for the assessment of asthmatic inflammation based on resolving cathepsin activity and matrix metalloproteinase activity in dust mite, ragweed, and Aspergillus species-challenged mice. The reconstructed multimodal fluorescence distribution showed good correspondence with ex vivo cryosection images and histological images, confirming FMT-XCT as an interesting alternative for asthma research.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Asthmatic Inflammation ; Dust Mite, Ragweed, And Aspergillus Species-challenged Mouse Model ; Fluorescence Molecular Tomography ; Multimodality Imaging ; X-ray Computed Tomography; Airway Inflammation; Mouse Models; Immunology; Contrast; Mice; Ct
ISSN (print) / ISBN
1083-3668
e-ISSN
1560-2281
Journal
Journal of Biomedical Optics
Quellenangaben
Volume: 21,
Issue: 1,
Article Number: 15009
Publisher
SPIE
Publishing Place
Bellingham
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)