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Open Access Green as soon as Postprint is submitted to ZB.
MALDI imaging mass spectrometry for direct tissue analysis: A new frontier for molecular histology.
Histochem. Cell Biol. 130, 421-434 (2008)
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful tool for investigating the distribution of proteins and small molecules within biological systems through the in situ analysis of tissue sections. MALDI-IMS can determine the distribution of hundreds of unknown compounds in a single measurement and enables the acquisition of cellular expression profiles while maintaining the cellular and molecular integrity. In recent years, a great many advances in the practice of imaging mass spectrometry have taken place, making the technique more sensitive, robust, and ultimately useful. In this review, we focus on the current state of the art of MALDI-IMS, describe basic technological developments for MALDI-IMS of animal and human tissues, and discuss some recent applications in basic research and in clinical settings.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
MALDI imaging mass spectrometry; Tissue; In situ-proteomics; Pathology
ISSN (print) / ISBN
0948-6143
e-ISSN
1432-119X
Journal
Histochemistry and Cell Biology
Quellenangaben
Volume: 130,
Issue: 3,
Pages: 421-434
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed