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Lu, Y.* ; Day, F.R.* ; Gustafsson, S.* ; Buchkovich, M.L.* ; Na, J.* ; Bataille, V.* ; Cousminer, D.L.* ; Dastani, Z.* ; Drong, A.W.* ; Esko, T.* ; Evans, D.M* ; Falchi, M.* ; Feitosa, M.F.* ; Ferreira, T.* ; Hedman, A.K.* ; Haring, R.* ; Hysi, P.G.* ; Iles, M.M.* ; Justice, A.E.* ; Kanoni, S.* ; Lagou, V.* ; Li, R.* ; Li, X.* ; Locke, A.* ; Lu, C.* ; Mägi, R.* ; Perry, J.R.* ; Pers, T.H.* ; Qi, Q.* ; Sanna, M.* ; Schmidt, E.M.* ; Scott, W.R.* ; Shungin, D.* ; Teumer, A.* ; Vinkhuyzen, A.A.* ; Walker, R.W.* ; Westra, H.J.* ; Zhang, M.* ; Zhang, W.* ; Zhao, J.H.* ; Zhu, Z.* ; Afzal, U.* ; Ahluwalia, T.S.* ; Bakker, S.J.* ; Bellis, C.* ; Bonnefond, A.* ; Borodulin, K.* ; Buchman, A.S.* ; Cederholm, T.* ; Choh, A.C.* ; Choi, H.J.* ; Curran, J.E.* ; de Groot, L.C.* ; de Jager, P.L.* ; Dhonukshe-Rutten, R.A.* ; Enneman, A.W.* ; Eury, E.* ; Evans, D.S.* ; Forsen, T.* ; Friedrich, N.* ; Fumeron, F.* ; Garcia, M.E.* ; Gärtner, S.* ; Han, B.G.* ; Havulinna, A.S.* ; Hayward, C.* ; Hernandez, D.* ; Hillege, H.* ; Ittermann, T.* ; Kent, J.W.* ; Kolcic, I.* ; Laatikainen, T.* ; Lahti, J.* ; Mateo Leach, I.* ; Lee, C.G.* ; Lee, J.Y.* ; Liu, T.* ; Liu, Y.* ; Lobbens, S.* ; Loh, M.* ; Lyytikäinen, L.-P.* ; Medina-Gomez, C.* ; Michaelsson, K.* ; Nalls, M.A.* ; Nielson, C.M.* ; Oozageer, L.* ; Pascoe, L.* ; Paternoster, L.* ; Polasek, O.* ; Ripatti, S.* ; Sarzynski, M.A.* ; Shin, C.S.* ; Narančić, N.S.* ; Spira, D.* ; Srikanth, P.* ; Steinhagen-Thiessen, E.* ; Sung, Y.J.* ; Swart, K.M.* ; Taittonen, L.* ; Tanaka, T.* ; Tikkanen, E.* ; van der Velde, N.* ; van Schoor, N.M.* ; Verweij, N.* ; Wright, A.F.* ; Yu, L.* ; Zmuda, J.M.* ; Eklund, N.* ; Forrester, T.* ; Grarup, N.* ; Jackson, A.U.* ; Kristiansson, K.* ; Kuulasmaa, T.* ; Kuusisto, J.* ; Lichtner, P. ; Luan, J.* ; Mahajan, A.* ; Männistö, S.* ; Palmer, C.D.* ; Ried, J.S. ; Scott, R.A.* ; Stancáková, A.* ; Wagner, P.J.* ; Demirkan, A.* ; Döring, A. ; Gudnason, V.* ; Kiel, D.P.* ; Kühnel, B. ; Mangino, M.* ; McKnight, B.* ; Menni, C.* ; O'Connell, J.R.* ; Oostra, B.A.* ; Shuldiner, A.R.* ; Song, K.* ; Vandenput, L.* ; van Duijn, C.M.* ; Vollenweider, P.* ; White, C.C.* ; Boehnke, M.* ; Boettcher, Y.* ; Cooper, R.S.* ; Forouhi, N.G.* ; Gieger, C. ; Grallert, H. ; Hingorani, A.* ; Jørgensen, T.* ; Jousilahti, P.* ; Kivimaki, M.* ; Kumari, M.* ; Laakso, M.* ; Langenberg, C.* ; Linneberg, A.* ; Luke, A.M.* ; McKenzie, C.A.* ; Palotie, A.* ; Pedersen, O.* ; Peters, A. ; Strauch, K. ; Tayo, B.O.* ; Wareham, N.J.* ; Bennett, D.A.* ; Bertram, L.* ; Blangero, J.* ; Blüher, M.* ; Bouchard, C.* ; Campbell, H.* ; Cho, N.H.* ; Cummings, S.R.* ; Czerwinski, S.A.* ; Demuth, I.* ; Eckardt, R.* ; Eriksson, J.G.* ; Ferrucci, L.* ; Franco, O.H.* ; Froguel, P.* ; Gansevoort, R.T.* ; Hansen, T.* ; Harris, T.B.* ; Hastie, N.* ; Heliövaara, M.* ; Hofman, A.* ; Jordan, J.M.* ; Jula, A.* ; Kähönen, M.* ; Kajantie, E.* ; Knekt, P.B.* ; Koskinen, S.* ; Kovacs, P.* ; Lehtimäki, T.* ; Lind, L.* ; Orwoll, E.S.* ; Osmond, C.* ; Perola, M.* ; Perusse, L.* ; Raitakari, O.T.* ; Rankinen, T.* ; Rao, D.C.* ; Rice, T.K.* ; Rivadeneira, F.* ; Rudan, I.* ; Salomaa, V.* ; Sørensen, T.I.* ; Stumvoll, M.* ; Tönjes, A.* ; Towne, B.* ; Tranah, G.J.* ; Tremblay, A.* ; Uitterlinden, A.G.* ; van der Harst, P.* ; Vartiainen, E.* ; Viikari, J.S.* ; Vitart, V.* ; Vohl, M.C.* ; Völzke, H.* ; Walker, M.* ; Wallaschofski, H.* ; Wild, S.* ; Wilson, J.F.* ; Yengo, L.* ; Bishop, D.T.* ; Borecki, I.B.* ; Chambers, J.C.* ; Cupples, L.A.* ; Dehghan, A.* ; Deloukas, P.* ; Fatemifar, G.* ; Fox, C.* ; Furey, T.S.* ; Franke, L.* ; Han, J.* ; Hunter, D.J.* ; Karjalainen, J.* ; Karpe, F.* ; Kaplan, R.C.* ; Kooner, J.S.* ; McCarthy, M.I.* ; Murabito, J.M.* ; Morris, A.P.* ; Bishop, J.A.* ; North, K.E.* ; Ohlsson, C.* ; Ong, K.K.* ; Prokopenko, I.* ; Richards, J.B.* ; Schadt, E.E.* ; Spector, T.D.* ; Widen, E.* ; Willer, C.J.* ; Yang, J.* ; Ingelsson, E.* ; Mohlke, K.L.* ; Hirschhorn, J.N.* ; Pospisilik, J.A.* ; Zillikens, M.C.* ; Lindgren, C.* ; Kilpeläinen, T.O.* ; Loos, R.J.*

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Nat. Commun. 7:10495 (2016)

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To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

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