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Guerreiro, R.* ; Escott-Price, V.* ; Darwent, L.* ; Parkkinen, L.* ; Ansorge, O.* ; Hernandez, D.G.* ; Nalls, M.A.* ; Clark, L.* ; Honig, L.* ; Marder, K.* ; van der Flier, W.* ; Holstege, H.* ; Louwersheimer, E.* ; Lemstra, A.* ; Scheltens, P.* ; Rogaeva, E.* ; St. George-Hyslop, P.H.* ; Londos, E.* ; Zetterberg, H.* ; Ortega-Cubero, S.* ; Pastor, P.* ; Ferman, T.J.* ; Graff-Radford, N.R.* ; Ross, O.A.* ; Barber, I.* ; Braae, A.* ; Brown, K.* ; Morgan, K.* ; Maetzler, W.* ; Berg, D.* ; Troakes, C.* ; Al-Sarraj, S.* ; Lashley, T.* ; Compta, Y.* ; Revesz, T.* ; Lees, A.* ; Cairns, N.J.* ; Halliday, G.M.* ; Mann, D.* ; Pickering-Brown, S.* ; Powell, J.* ; Lunnon, K.* ; Lupton, M.K.* ; International Parkinson's Disease Genomics Consortium (IPDGC) (Illig, T. ; Lichtner, P.) ; Dickson, D.W.* ; Hardy, J.* ; Singleton, A.* ; Bras, J.*

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Neurobiol. Aging 38, 214.e7-214.e10 (2016)

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The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Alzheimer's Disease ; Dementia With Lewy Bodies ; Genetic Correlation ; Parkinson's Disease

ISSN (print) / ISBN 0197-4580

e-ISSN 1558-1497

Journal Neurobiology of Aging

Quellenangaben Volume: 38, Pages: 214.e7-214.e10

Publisher Elsevier

Publishing Place New York, NY [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)
Institute of Human Genetics (IHG)