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Guerreiro, R.* ; Escott-Price, V.* ; Darwent, L.* ; Parkkinen, L.* ; Ansorge, O.* ; Hernandez, D.G.* ; Nalls, M.A.* ; Clark, L.* ; Honig, L.* ; Marder, K.* ; van der Flier, W.* ; Holstege, H.* ; Louwersheimer, E.* ; Lemstra, A.* ; Scheltens, P.* ; Rogaeva, E.* ; St. George-Hyslop, P.H.* ; Londos, E.* ; Zetterberg, H.* ; Ortega-Cubero, S.* ; Pastor, P.* ; Ferman, T.J.* ; Graff-Radford, N.R.* ; Ross, O.A.* ; Barber, I.* ; Braae, A.* ; Brown, K.* ; Morgan, K.* ; Maetzler, W.* ; Berg, D.* ; Troakes, C.* ; Al-Sarraj, S.* ; Lashley, T.* ; Compta, Y.* ; Revesz, T.* ; Lees, A.* ; Cairns, N.J.* ; Halliday, G.M.* ; Mann, D.* ; Pickering-Brown, S.* ; Powell, J.* ; Lunnon, K.* ; Lupton, M.K.* ; International Parkinson's Disease Genomics Consortium (IPDGC) (Illig, T. ; Lichtner, P.) ; Dickson, D.W.* ; Hardy, J.* ; Singleton, A.* ; Bras, J.*

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Neurobiol. Aging 38, 214.e7-214.e10 (2016)
Publ. Version/Full Text Supplement DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Alzheimer's Disease ; Dementia With Lewy Bodies ; Genetic Correlation ; Parkinson's Disease
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0197-4580
e-ISSN 1558-1497
Journal Neurobiology of Aging
Quellenangaben Volume: 38, Issue: , Pages: 214.e7-214.e10 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504091-001
G-500700-001
DOI 10.1016/j.neurobiolaging.2015.10.028
PubMed ID 26643944
Erfassungsdatum 2016-02-11
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