PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Thiering, E. ; Markevych, I. ; Brüske, I. ; Fuertes, E. ; Kratzsch, J.* ; Sugiri, D.* ; Hoffmann, B.* ; von Berg, A.* ; Bauer, C.P.* ; Koletzko, S.* ; Berdel, D.* ; Heinrich, J.

Associations of residential long-term air pollution exposures and satellite-derived greenness with insulin resistance in German adolescents.

Environ. Health Perspect. 124, 1291-1298 (2016)
Publ. Version/Full Text Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Epidemiological studies have identified associations between air pollution and green space access with type 2 diabetes in adults. However it remains unclear to what extent associations with greenness are attributable to air pollution exposure. OBJECTIVES: We aimed to investigate associations between long-term exposure to air pollution and satellite-derived greenness with insulin resistance in adolescents. METHODS: 837 participants of two German birth cohorts (LISAplus and GINIplus) were included in the analysis. Generalized additive models were used to determine the association of individual satellite-derived greenness defined by the Normalized Difference Vegetation Index (NDVI), long-term air pollution exposure estimated by land-use regression (LUR) models with insulin resistance (HOMA-IR) in 15 year-old adolescents. Models were adjusted for study area, cohort, socioeconomic, and individual characteristics such as BMI, physical activity, and smoking. RESULTS: 2-SD increases in nitrogen dioxide (NO2, 8.9 μg/m(3)) and particulate matter smaller than 10μm in diameter (PM10, 6.7 μg/m(3)) were significantly associated with 11.4% (95% CI: 4.4, 18.9) and 11.4% (95% CI: 0.4, 23.7) higher HOMA-IR. A 2-SD increase in NDVI in a 1000m buffer (0.2 units) was significantly associated with a lower HOMA-IR (-7.4% (95% CI: -13.3, -1.1)). Associations tended to be stronger in adolescents who spent more time outside and those with a lower socioeconomic status. In combined models including both air pollution and greenness, only NO2 remained significantly associated with HOMA-IR, while effect estimates for all other exposures attenuated after adjustment for NO2. CONCLUSIONS: NO2, often considered as a marker of traffic, was independently associated with insulin resistance. The observed association between higher greenness exposure and lower HOMA-IR in adolescents might thus be mainly due to the lower co-exposure to traffic-related air pollution.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
8.443
2.217
72
101
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Fine Particulate Matter; Type-2 Diabetes-mellitus; Use Regression-models; Physical-activity; Cohort; Children; Risk; No2; Metaanalysis; Mortality
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Journal Environmental Health Perspectives
Quellenangaben Volume: 124, Issue: 8, Pages: 1291-1298 Article Number: , Supplement: ,
Publisher Research Triangle Park
Publishing Place NC [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
G-503900-003
PubMed ID 26863688
DOI 10.1289/ehp.1509967
WOS ID WOS:000380749900029
Scopus ID 84980316328
Erfassungsdatum 2016-02-12
[➜Report correction]