PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Kang, X.* ; Liu, H.* ; Onaitis, M.W.* ; Liu, Z.* ; Owzar, K.* ; Han, Y.* ; Su, L.* ; Wei, Y.* ; Hung, R.J.* ; Brhane, Y.* ; McLaughlin, J.* ; Brennan, P.* ; Bickeböller, H.* ; Rosenberger, A.* ; Houlston, R.S.* ; Caporaso, N.* ; Landi, M.T.* ; Heinrich, J. ; Risch, A.* ; Wu, X.* ; Ye, Y.* ; Christiani, D.C.* ; Amos, C.I.* ; Wei, Q.* ; Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team (*)

Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: A meta-analysis of 14 463 cases and 44 188 controls.

Carcinogenesis 37, 280-289 (2016)
Publ. Version/Full Text Supplement DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Centrosome abnormalities are often observed in premalignant lesions and in situ tumors and have been associated with aneuploidy and tumor development. We investigated the associations of 9354 single-nucleotide polymorphisms (SNPs) in 106 centrosomal genes with lung cancer risk by first using the summary data from six published genome-wide association studies (GWASs) of the Transdisciplinary Research in Cancer of the Lung (TRICL) (12 160 cases and 16 838 controls) and then conducted in silico replication in two additional independent lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1319 cases and 26 380 controls). A total of 44 significant SNPs with false discovery rate (FDR) ≤ 0.05 were mapped to one novel gene FGFR1OP and two previously reported genes (TUBB and BRCA2). After combined the results from TRICL with those from Harvard and deCODE, the most significant association (P combined = 8.032×10(-6)) was with rs151606 within FGFR1OP. The rs151606 T>G was associated with an increased risk of lung cancer [odds ratio (OR) = 1.10, 95% confidence interval (95% CI) = 1.05-1.14]. Another significant tagSNP rs12212247 T>C (P combined = 9.589×10(-6)) was associated with a decreased risk of lung cancer (OR = 0.93, 95% CI = 0.90-0.96). Further in silico functional analyzes revealed that rs151606 might affect transcriptional regulation and result in decreased FGFR1OP expression (P trend = 0.022). The findings shed some new light on the role of centrosome abnormalities in the susceptibility to lung carcinogenesis.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.874
1.315
5
5
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Susceptibility Locus; Disease; Amplification; Abnormalities; Vitiligo; Variants; Cells; Visualization; Instability
Language english
Publication Year 2016
HGF-reported in Year 2016
ISSN (print) / ISBN 0143-3334
e-ISSN 1460-2180
Journal Carcinogenesis
Quellenangaben Volume: 37, Issue: 3, Pages: 280-289 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
DOI 10.1093/carcin/bgw014
WOS ID WOS:000371696400006
Scopus ID 84959877489
PubMed ID 26905588
Erfassungsdatum 2016-02-27
[➜Report correction]