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PARP activation promotes nuclear AID accumulation in lymphoma cells.
Oncotarget 7, 13197-13208 (2016)
Activation-induced cytidine deaminase (AID) initiates immunoglobulin diversification in germinal center B cells by targeted introduction of DNA damage. As aberrant nuclear AID action contributes to the generation of B cell lymphoma, the protein's activity is tightly regulated, e.g. by nuclear/cytoplasmic shuttling and nuclear degradation. In the present study, we asked whether DNA damage may affect regulation of the AID protein. We show that exogenous DNA damage that mainly activates base excision repair leads to prevention of proteasomal degradation of AID and hence its nuclear accumulation. Inhibitor as well as knockout studies indicate that activation of poly (ADP-ribose) polymerase (PARP) by DNA damaging agents promotes both phenomena. These findings suggest that PARP inhibitors influence DNA damage dependent AID regulation, with interesting implications for the regulation of AID function and chemotherapy of lymphoma.
Impact Factor
Scopus SNIP
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Times Cited
Times Cited
Scopus
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Cited By
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5.008
1.071
5
6
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dna Damage ; Activation-induced Cytidine Deaminase ; Lymphoma ; Poly (adp-ribose) Polymerase ; Protein Stability; Induced Cytidine Deaminase; Class-switch Recombination; Dna-damage Response; Protein-kinase-a; Somatic Hypermutation; Homologous Recombination; Genomic Uracil; B-cells; Phosphorylation; Mechanisms
Language
english
Publication Year
2016
HGF-reported in Year
2016
ISSN (print) / ISBN
1949-2553
e-ISSN
1949-2553
Journal
OncoTarget
Quellenangaben
Volume: 7,
Issue: 11,
Pages: 13197-13208
Publisher
Impact Journals LLC
Reviewing status
Peer reviewed
Institute(s)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
Institute of Molecular Immunology (IMI)
Institute of Molecular Immunology (IMI)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-501490-001
G-501793-001
G-501793-001
WOS ID
WOS:000375679600108
Scopus ID
84962868923
PubMed ID
26921193
Erfassungsdatum
2016-02-29