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Open Access Green as soon as Postprint is submitted to ZB.
The role of immune cells in metabolism-related liver inflammation and development of Non-Alcoholic Steatohepatitis (NASH).
Rev. Endocr. Metab. Disord. 17, 29-39 (2016)
The low grade inflammatory state present in obesity promotes the progression of Non-Alcoholic Fatty Liver Disease (NAFLD). In Non-Alcoholic Steatohepatitis (NASH), augmented hepatic steatosis is accompanied by aberrant intrahepatic inflammation and exacerbated hepatocellular injury. NASH is an important disorder and can lead to fibrosis, cirrhosis and even neoplasia. The pathology of NASH involves a complex network of mechanisms, including increased infiltration of different subsets of immune cells, such as monocytes, T-lymphocytes and neutrophils, to the liver, as well as activation and in situ expansion of liver resident cells such as Kupffer cells or stellate cells. In this review, we summarize recent advances regarding understanding the role of the various cells of the innate and adaptive immunity in NASH development and progression, and discuss possible future therapeutic options and tools to interfere with disease progression.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hepatic Stellate Cells (hsc) ; Kupffer Cells ; Non-alcoholic Steatohepatitis (nash) ; Obesity ; Steatosis ; T-regulatory Cells (tregs); Hepatic Stellate Cells; Regulatory T-cells; Adipose-tissue Inflammation; Diet-induced Obesity; Activation In-vivo; Collagen Type-i; High-fat Diet; Insulin-resistance; Kupffer Cells; Dendritic Cells
ISSN (print) / ISBN
1389-9155
e-ISSN
1573-2606
Quellenangaben
Volume: 17,
Issue: 1,
Pages: 29-39
Publisher
Springer
Publishing Place
Boston
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)