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Reitmeir, P. ; Linkohr, B. ; Heier, M. ; Molnos, S. ; Strobl, R.* ; Schulz, H. ; Grallert, H. ; Grill, E. ; Peters, A. ; Graw, J.

Common eye diseases in older adults of Southern Germany: Results from the KORA-Age study.

Vortrag: Health – Exploring Complexity (HEC2016), 28th August -2nd September 2016, Munich, Germany. (2016)
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Open Access Green as soon as Postprint is submitted to ZB.
© The Author 2016.Purpose: a population-based study in the region of Augsburg (Germany, KORA) was used to identify the prevalence of eye diseases and their risk factors in a sample of aged individuals. Methods: data originated from the KORA-Age study collected in 2012 and 822 participants (49.6% women, 50.4% men, aged 68-96 years) were asked standardised questions about eye diseases. Positive answers were validated and specified by treating ophthalmologists. Additional information came from laboratory data. Polymorphic markers were tested for candidate genes. Results: we received validations and specifications for 339 participants. The most frequent eye diseases were cataracts (299 cases, 36%), dry eyes (120 cases, 15%), glaucoma (72 cases, 9%) and age-related macular degeneration (AMD) (68 cases, 8%). Almost all participants suffering from glaucoma or from AMD also had cataracts. Cataract surgery was associated with diabetes (in men; OR = 2.24; 95% confidence interval [CI] 1.11-4.53; P = 0.025) and smoking (in women; OR = 6.77; CI 1.62-28.35; P = 0.009). In men, treatments in airway diseases was associated with cataracts (glucocorticoids: OR = 5.29, CI 1.20-23.37; P = 0.028; sympathomimetics: OR = 4.57, CI 1.39-15.00; P = 0.012). Polymorphisms in two genes were associated with AMD (ARMS2: OR = 2.28, CI 1.48-3.51; P = 0.005; CFH: OR = 2.03, CI 1.35-3.06; P = 0.010). Conclusion: combinations of eye diseases were frequent at old age. The importance of classical risk factors like diabetes, hypertension and airway diseases decreased either due to a survivor bias leaving healthier survivors in the older age group, or due to an increased influence of other up to now unknown risk factors.
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Publication type Other: Lecture
Corresponding Author
Keywords Ageing ; Amd ; Cataract ; Glaucoma ; Older People ; Population Study
ISSN (print) / ISBN 0002-0729
e-ISSN 1468-2834
Conference Title Health – Exploring Complexity (HEC2016)
Conference Date 28th August -2nd September 2016
Conference Location Munich, Germany
Journal Age and Ageing
Quellenangaben Volume: 46, Issue: 3, Pages: 481-486 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Health Economics and Health Care Management (IGM)
Institute of Epidemiology (EPI)